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ScienceNews 2010 08
2010-11-08 11:59:13
When a bad bacterium infects tumor cells, it can signal the body to fight the deadliest form of skin cancer. Scientists already knew that diarrhea-causing Salmonella typhimurium helps the immune system recognize melanoma, but a paper in the Aug. 11 Science Translational Medicine shows how. The finding may point to a new human vaccine for melanoma and possibly other kinds of cancer. “In combination with other therapies, it could improve survival,” says tumor biologist Meenhard Herlyn of the Wistar Institute in Philadelphia. But melanoma is such a complex cancer that a vaccine probably couldn’t cure the disease permanently, adds Herlyn, who was not involved with the study. When Salmonella was injected into mouse melanoma tumors, those tumors shrank, as did untreated tumors in other parts of the body. Experiments showed that the process relied on the presence of a protein channel called connexin 43 on the surface of melanoma cells.. That protein channel allows the cells to connect to similar channels in immune cells, forming ‘gap junctions’ that allow the two cells to share their contents. Salmonella got into the tumor cells and caused them to rev up production of the channel-forming protein. Those protein channels connected with immune cells and allowed bits of tumor proteins to pass through. The immune cells, called dendritic cells, then displayed the bits of tumor protein on their own surfaces. In doing so, they activated other immune cells to find and kill tumor cells bearing those same proteins. “We now have a ‘gun’ to kill specifically tumor cells,” says lead study author Maria Rescigno, an immunologist from the European Institute of Oncology in Milan. “We are inducing an immune response to that ‘fingerprint’ which is specific for the tumor.” Rescigno and her team think they could use the new knowledge about how the salmonella treatment works to produce human vaccines against melanoma and other types of cancers. Her team successfully vaccinated mice against melanoma by injecting them with the bacteria-treated melanoma cells. Instead of injecting patients with salmonella, researchers could instead teach the patient’s own immune cells to recognize tumors in the lab. By mixing the patient’s tumor cells with Salmonella and then the patient’s own immune cells, those immune cells would learn to target tumor cells specifically. Those “educated” immune cells could then be injected back into a patient’s body to attack the cancer. Melanoma is believed to be influenced by genetics and also to be caused by sun exposure. Once the cancer has spread to other body organs, the five-year survival rate is below 15 percent and there is no cure. Like other cancers, one way melanoma hides from the immune system is by removing membrane proteins on its cell surfaces that would otherwise connect with the body’s immune system. Rescigno is already in the process of getting authorization from the Italian Ministry of Health to start human trials of a vaccine. “We hope by May or June next year to have the protocol in the clinics for treating melanoma patients,” she says.................. http://www.sciencenews.org/view/generic/id/62021/title/How_salmonella_helps_kill_cancer_cells
Auris
2010-11-07 22:42:33
Dabar perskaiciau ir straipsni , kuriame tirta salmonelioze, kuri organizme padeda aptikti imuninei vezines lasteles, tai jau dare ne veterinarai.
kliedesys
2010-11-07 14:44:18
Gal straipsnio autorius tegul uzvalgo mesos su trichenelemis o po menesio (jei bus dar gyvas) paraso ispudzius apie imuniteto sustiprejima..
mecislovas v
2010-11-06 10:09:36
žmogaus organizmas simbiotiškas-tai žino beveik kiekvienas.Ir tai reiškia kad jame gyvena daugelis gyvo pasaulio atstovų-bakterijos,kirmėlės,pirmuonys,grybeliai ,nariuotakojai...Sutinku,kad tai gerai,bet tik iki tam tikros normos,iki tol kol jų nedaug.Jei jų daug ,tada organizmas nesusitvarko su jų kiekiu ir tada suserga ūmia infekcija-tai irgi juk labai suprantama. Pasaulyje visi maitinasi kitais-parazitai irgi kažkuo maitinasi. Aš ,atsimenu,vaikystėje esu turėjęs helmintinę infekciją-o vėliau ,jau apie 30 gyvenimo metus prasidėjo ligos,po 2-3 kartus metuose tekdavo gulėti ligoninėse ir gydytojai nieko negalėjo padaryti. tik L.G.Pučko metodika išsiaiškinau savo ligotumo priežastis-organizme esantys parazitai,jų kolektyvinio proto energoinformacinis poveikis,parazitų sukurtos palaikomosios jų gyvybingumą eneroinformacinės struktūros daro mano imunitetą neveiklų,silpną tiek ląsteliniu tiek ir humoraliniu lygiais.Gydymo procese buvo pašalintos energoinformacinės struktūros,po to ir kirmėlės,kiti parazitai ir organizmo ligotumas išnyko... jau 15 metų praėjo ,kai net gripas ,slogavimai,anginos,odos seborėja,nervingumas išnyko ir nesikartoja,esu visiškai ramus dėl gripo ir kt epidemijų-žinau,kad tiesiog neįmanoma susirgti... Tik maži infekcijų kiekiai organizmui yra nepavojingi ir pračiau,pasakykite,kokiais metodais visą tai gali kontroliuoti kiekvienas iš žmonių asmeniškai? manau,kad jokiais metodais tai nekontroliuojama,jei kartą atėjo į organizmą patogeninis agentas-virusas,bakterijos,kirmėlės ir grybeliai,tai jie savanoriškai jau niekada neišeis iš organizmo ir toliau maitinsis gyvomis kūno ląstelėmis ,maitinsis visu tuo ,kuo mes isintame patys,sukurdami organizme mikroelementinį deficitą,mųsų organizmą pritaikydami savo egzistencijai... Jei žmogutis sutinka kad jo kūne gyventų ir parazitai-tai jo asmeninis reikalas,tačiau dėl savo sprendimo tada nereikia niekam ir skūstis kad skauda ....
Jei ka
2010-11-05 15:56:05
tai šernai apskritai nebūna riebūs niekada. čia ne kiaulės kurios tukinamos belenkaip.
Judai,
2010-11-04 14:57:14
daug riebių šernų randa medžiotojai, nustipusių nuo CNS, infarkto, plaučių paralyžiaus?
judas
2010-11-02 21:09:20
Jums ryškiai trūksta informacijos :) ypač juokinga klausytis jog jūsų šaltinis wikipedia.... kodėl nepaminėtas mirtingumas sergant trichinelioze? CNS, miokardo pažeidimai.. jei pasiseka trichinelės persistuoja raumenyse ir tik sumažina jų funkciją. o neretai atsiranda kvėpavimo paralyžius, ataksija ir kiti CNS pažeidimai. Skleisdama tokią informaciją jūs ryškiai kažkuo suinteresuota.
luna
2010-11-02 14:12:55
na, aš galvoju, kad galbūt su laiku jie labai "išbujoja" ir pradeda skriausti savo šeimininką, ypatingai, jeigu jo organizmas nusilpsta. o kadangi civilizacija ugdo mus tokiais silpniukais ;) tai ir stengiamasi eliminuoti tuos parazitus nebesigilinant į jų teikiamą (laikiną?) naudą.
Beuzsukantis
2010-11-02 13:33:55
Na taip, idomus poziuris. Mane irgi kankina tas klausimas, kodel gamtoje yra "parazitu", juk ju teoriskai neturetu buti - bet tai tik parodo, kad musu teorija nepilna. Net oficialus veterinarijos tarnybos puslapis ar wikipedia nepateikia, kodel trichinelioze yra blogai (karsciavimas ir raumenu skausmai nesiskaito, nes tai praeinantys simptomai): http://www.nmvrvi.lt/lt/zoonozes/trichinelioze/ Siame straipsnyje irgi nesiulo visa gyvenima nesioti tos kirmeles savo raumenyse, tai man idomu, kodel net toki geradari vis tiek siulo isvaryti po 12 dienu?
edai
2010-10-31 18:49:00
na, visų pirma, tai medicinos siūlomos vakcinos suleidžiamos tiesiai į kraują, apeinant visas užsikrėtimo stadijas, ko nėra Britovo vakcinavimo atveju. Antra, Britovas nesiūlo gerti jo vakciną kiekvienam, kaip tai daro medicina. Trečia Britovas neskirsti į vakciną nuo konkrečių ligų ir neskiepija dvidešimčia vakcinų, kaip tai daro medicina – naudinga matyt jai. Penkta – reiktų skirti medicinos siūlomas SPECIFINES vakcinas, nuo Britovo siūlomos vakcinos, kurios pagalba skatinamas bendras ląstelinis imunitetas. Specifinio vakcinavimo atveju antikūnas gaminamas tik prieš konkretų antigeną. Šešta – turbūt sutiksite, jo vakcinos priedas pienas yra mažiau kenksmingas, negu gyvsidabris ar aliuminis. Britovo vakcina – gydymo priemonė, medicinos siūlomos - profilaktinės. Britovas ne pirmas atrado gydymo metodiką su vakcinomis. Jau seniai yra žinomi gydymo metodai, pvz, su Gonovakcina ar, tarkim, Pyrogenalu, kai stimuliuojamas bendras imunitetas.
Saulius
2010-10-31 13:06:26
Nu va, pagaliau. Visada jaučiau, kad negerai plaut vaisius ar daržoves, taip pat rankas prieš valgį. Bet niekas tuo netikėjo...
essence
2010-10-31 12:43:42
Ir vėl kaip kirviu nukirsta.
eda
2010-10-31 11:56:40
As nesuprantu skirtumo tarp gyvu vakcinu, brukamu musu medicinos, kurias apibudinate kaip blogi, ir sio rusu daktaro siulomu gyvu vakcinu su helmintais. Abi teoriskai stimuliuoja imuniteta. Koks skirtumas? Kodel vienos blogos, kitos geros?
luna
2010-10-30 23:06:59
klausykit, nu kaip tik kokia telepatija :D vakar vermoxa pirkaus - turiu gi labai mielą šuniuką; bent kartą metuose, o geriau ir du, sako, reikia jam kirminukus išvaryti. o kadangi šuniukas visur aplink, rankų nepriplausi.....tai ir šeimininkai turi vaistukų sugert. taip sako veterinarai. tai gert man dabar ar negert tą vermoxą? ar reikia suprasti, kad tik spec.trichinelos yra naudingos, o kiti kirminai iš tikro kenkia sveikatai? (o šiandien dar brolienė kaip tik pasakė, kad savo mažiesiems kas pusę metų po tabletę vermoxo profilaktiškai duoda. hm....man pasirodė kad gal čia jau per daug.....)

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